Lightweight, fast and reliable - these are the core tenets of CentOS. It is one of the best Enterprise-level operating systems that aims for speed and stability, without cutting out security. Inspired by Red Hat Enterprise Linux, CentOS is also a formidable option for VPS hosting. When in doubt, pick the go-to web server operating system around the world. Power, robustness, and flexibility guaranteed!
To break things down a bit, cloud VPS (Virtual Private Server) hosting is when a web hosting provider takes one massive server and partitions it up so that it can have several servers on it, each of which can run its own operating system and can be re-booted independently.  Sounds simple enough.  So what is the difference between managed VPS and unmanaged VPS?

InMotion Hosting's Virtual Private Servers are now using Solid State Drives (SSDs), a type of hard drive that uses no mechanical parts and provides substantial performance upgrades from traditional spinning drives. Solid State Drives give you faster read/write speeds, can handle more disk requests and can push through significantly more data than a standard Hard Disk Drive (HDD).
You can host a basic web application, such as a blog or simple website in a VPC, and gain the additional layers of privacy and security afforded by Amazon VPC. You can help secure the website by creating security group rules which allow the webserver to respond to inbound HTTP and SSL requests from the Internet while simultaneously prohibiting the webserver from initiating outbound connections to the Internet. You can create a VPC that supports this use case by selecting "VPC with a Single Public Subnet Only" from the Amazon VPC console wizard.

In terms of backups, databases and files, it all depends on the type of setup you choose. If you choose a server with a control panel it will make it effortless but if you want to do it manually, i suggest you take some time to learn how to do it properly, because, one error and you might loose everything you have worked for. My suggestion for a best server setup is a cloud managed cPanel VPS with SSD and good backup tool.
I was in a similar situation about a year ago, had a managed VPS for some years before i needed a better server and had to switch to an un-managed VPS. Although i had another un-managed VPS without a control panel previously, this time round i chose an un-managed box with cPanel already installed. This was quite handy as i didn't have to deal with installing and licencing the control panel. As have always used cPanel, setting up sites, databases, DNS and all the other configurations was straight forward and fast.
A VPS is an excellent choice for web developers, webmasters, resellers, and for those who run resource-intensive websites. Each VPS Plan under Namecheap operates and performs exactly how an independent physical machine would, featuring security and flexibility for your websites, independence from neighbors, full control over your hosting environment, and Dedicated Server power. The best part? It's all at an affordable price.
You can easily customize the network configuration for your Amazon VPC. For example, you can create a public-facing subnet for your web servers that has access to the Internet, and place your backend systems such as databases or application servers in a private-facing subnet with no Internet access. You can leverage multiple layers of security, including security groups and network access control lists, to help control access to Amazon EC2 instances in each subnet.